On X-ray scattering model for single particles, Part II: Beyond protein crystallography

Emerging coherent X-ray scattering patterns of single-particles have shown dominant morphological signatures in agreement with predictions of the scattering model used for conventional protein crystallography. The key question is if and to what extent these scattering patterns contain volumetric information, and what model can retrieve it. This contribution is Part 2 out of two reports, in which we seek to clarify the assumptions of some different regimes and models of X-ray scattering and their implications for single particle imaging. In Part 1, basic concepts and existing scattering models along with their implications for nanocrystals, and also the misconception of using Diffraction Theory for volumetric scattering were addressed. Here in Part 2, specific challenges ahead of single particle imaging are addressed. 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